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Martin Fussenegger, Ph.D., lead author and professor at ETH Zurich, and his team of researchers created “microencapsulated human designer cells” that produce Huwentoxin-IV, an analgesic peptide that shuts down Nav1.7, a pain-inducing sodium channel. Then, they altered an olfactory receptor, OR1A1, that is responsive to R-carvone, a chemical that smells like spearmint.
In other words, in this mechanism, the smell of spearmint triggers the production of Huwentoxin-IV, which eliminates pain.
These “AromaCells” were tested in mouse models, and the results suggest that the mice experienced lasting pain relief when exposed to spearmint. It also bypasses one of the biggest, if not the biggest, problems associated with pain treatment.
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With the United States in the midst of a public health crisis, this study draws attention to an unheard of approach to pain management. This mechanism targets pain without producing the pleasurable, euphoric sensations prescription opioids induce. Although this strategy is nascent, it’s still a significant advancement in chronic pain management.
Until pain treatment alternatives like Fussenegger’s become universal, Guardian Recovery will be actively working to combat the opioid epidemic. Our specialized services and expert clinical and medical staff have helped hundreds of people overcome opioid addiction and achieve permanent, lasting recovery. For more information about how our addiction treatment services can help you or someone you care about, contact a Guardian Recovery Specialist at 877.831.2533.
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