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The Dangers of Mixing Alcohol & Nyquil

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If you have ever had a cold, headache, the flu, or experienced allergies, you may have taken Nyquil to help alleviate some of these symptoms. Every year, there are approximately 1 billion colds caught by Americans. (1) The influenza, or flu, affects approximately 5 to 20 percent of individuals. (2) Combining Nyquil and other substances has become a new trend, especially for younger adolescents and adults. If you are taking Nyquil, it is important to understand its interactions with substances such as alcohol. Alcohol can have some dangerous side effects when mixed with certain medications. (3)

If you need to take Nyquil to relieve unwanted symptoms, ceasing alcohol use is crucial for your continued health. It may be difficult to stop all alcohol use if you are used to consuming alcohol excessively, chronically, or daily. If you find it difficult to control your alcohol use, or stop when necessary, you may be experiencing alcohol use disorder. Here at Guardian Recovery, we provide psychoeducation and therapeutic interventions to aid you in maintaining a sober lifestyle. With dual diagnosis options, we can provide treatment for alcohol use and other mental health diagnoses. Contact us today to learn more about our treatment options.

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What Is Nyquil?

Nyquil is a medication that can be found over the counter. (4) Nyquil is the combination of acetaminophen, dextromethorphan, and doxylamine. Acetaminophen treats pain and reduces fever. Dextromethorphan targets the part of the brain that initiates coughs and suppresses them. (5) Doxylamine is an antihistamine, which treats allergies, sneezes, watery eyes, and runny noses. (6) Nyquil can be used in the form of capsules, liquid, or a combination of the two, known as LiquiCaps. No more than 4 doses of Nyquil should be taken during a 24 hour period.

Can You Mix Alcohol & Nyquil?

Mixing alcohol and Nyquil can lead to serious side effects. If you are taking Nyquil, it is probably due to you being infected with a cold or the flu. If you are under the weather, consuming alcohol could make you feel worse. It could induce a headache, tiredness, or dehydration. Your immune system could be weakened if you are sick and also drinking alcohol. (7) Alcohol reduces the amount of white blood cells present within the body, which helps fight off diseases and infections. (8)

It is also important to note that the liquid version of Nyquil already contains 10 percent of alcohol, while the LiquiCaps contain none. There are other Nyquil products that do not contain alcohol such as Children’s Nyquil (9) and Alcohol-Free NyQuil Cold & Flu Nighttime Relief Liquid. (10) Though these two products do not contain alcohol, they may include certain ingredients that could interact negatively with alcohol. Alcohol can enhance the effects of Nyquil, leading to unwanted side effects.

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Alcohol & Nyquil Side Effects

Nyquil and alcohol have their own sets of side effects when taken separately.

Side effects associated with chronic, excessive, or daily alcohol use include: (11)

  • Mood and behavior changes
  • Coordination and cognitive impairments
  • Impairments with the immune system
  • Cardiovascular problems
  • Liver problems
  • Pancreas impairments
  • Development of certain cancers

Consuming too much alcohol in a short period of time can lead to alcohol poisoning. (12) Alcohol poisoning can include symptoms such as confusion, vomiting, slow breathing, coma, or death. If you suspect that you are experiencing any symptoms of alcohol poisoning, it is important to seek immediate medical attention.

Common side effects of Nyquil are often mild and nonthreatening. They include: (13)

  • Difficulties falling or staying asleep
  • Stomachache
  • Blurry vision
  • Dry eyes, mouth, or nose
  • Mild drowsiness and dizziness
  • Excitedness or restlessness, mostly seen in children
  • Mild rashes

Taking more than the recommended dose of Nyquil, can lead to overdosing. (14) Overdosing can be fatal depending on how much of the substance has been consumed. It is important to seek medical attention if you are experiencing seizures, anxiety, hallucinations, hyperactivity, or dilated pupils after taking Nyquil.

Since these substances have their own list of side effects, it is understandable why combining the two can lead to more extreme or exasperated symptoms. Impairments within the liver is one of the main risks of combining alcohol and Nyquil. (15) Those with prior liver disease should discuss with their doctor if Nyquil is the right medication for them and their symptoms. The acetaminophen present in Nyquil can put additional stress on the liver. Doxylamine, one of the other ingredients in Nyquil, can cause extreme sedation when mixed with alcohol.

The company which manufactures Nyquil warns against combining alcohol and the medication. (16). It recommends avoiding all alcoholic beverages when taking Nyquil as it can cause extreme drowsiness. Due to the drowsiness caused by mixing these two substances, it is important to take caution when operating a motor vehicle or machinery. Both alcohol and Nyquil depress the central nervous system, which affects the brain and the spinal cord. When the central nervous system is slowed down, there can be impairs in coordination and alertness. (17)

Combining these two substances can increase your chances of experiencing an overdose. Overdose can occur when mixing alcohol and Nyquil, and sometimes can be difficult to notice. Symptoms that can occur when experiencing an alcohol and Nyquil overdose include:

  • Severe confusion
  • Rapid heart beat
  • Stomachache
  • Hallucinations
  • Seizures

Seek immediate medical attention if you or a loved one are experiencing any of the above symptoms.

Alcohol & Nyquil Addiction

Addiction is a complex chemical imbalance which affects the brain. Over 14.5 million individuals experience an alcohol use disorder. Mixing alcohol and Nyquil only exacerbates this problem. Nyquil, and other over the counter medication, is often subject to misuse due to the side effects that are elicited when too much is consumed. In addition, Nyquil and alcohol can induce feelings of pleasure in the reward systems within the brain, leading to the body wanting more.

Like Nyquil, alcohol is easily accessible, making it easy to become dependent on one or both substances. A 2019 study found that approximately 3 percent of adolescents used doxylamine, which can be found in Nyquil, to reach psychological effects. (18) An alcohol and Nyquil addiction may look like neglecting responsibilities at home, work, or other important areas. It may lead you to engage in dangerous or risky behaviors. Dependence on alcohol is likely to develop if one continuously misuses alcohol and Nyquil substances. Recovering from having a dependence on any substance can be difficult. Understanding the risks involved can make it easier to make healthy and informed decisions.

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  1. https://www.nccih.nih.gov/health/flu-and-colds-in-depth
  2. https://www.nccih.nih.gov/health/flu-and-colds-in-depth
  3. https://www.niaaa.nih.gov/publications/brochures-and-fact-sheets/harmful-interactions-mixing-alcohol-with-medicines
  4. https://www.drugs.com/mtm/nyquil-cold-flu.html
  5. https://www.ncbi.nlm.nih.gov/books/NBK538216/
  6. https://www.ncbi.nlm.nih.gov/books/NBK551646/
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590612/#:~:text=Alcohol%20disrupts%20ciliary%20function%20in,article%20by%20Simet%20and%20Sisson
  8. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/white-blood-cell
  9. https://vicks.com/en-us/shop-products/childrens-products/childrens-nyquil-tm-cold-and-cough-medicine

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Reviewed professionally for accuracy by:

Ryan Soave

L.M.H.C.

Ryan Soave brings deep experience as a Licensed Mental Health Counselor, certified trauma therapist, program developer, and research consultant for Huberman Lab at Stanford University Department of Neurobiology. Post-graduation from Wake Forest University, Ryan quickly discovered his acumen for the business world. After almost a decade of successful entrepreneurship and world traveling, he encountered a wave of personal and spiritual challenges; he felt a calling for something more. Ryan returned to school and completed his Master’s Degree in Mental Health Counseling. When he started working with those suffering from addiction and PTSD, he found his passion. He has never looked back.

Written by:

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Cayla Clark

Cayla Clark grew up in Santa Barbara, CA and graduated from UCLA with a degree in playwriting. Since then she has been writing on addiction recovery and psychology full-time, and has found a home as part of the Guardian Recovery team.

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The information provided on this website is intended solely for educational and informational purposes. Guardian Recovery aims to improve the quality of life for individuals struggling with substance use or mental health disorders by offering fact-based content about behavioral health conditions, treatment options, and related outcomes. However, this information should not be considered a substitute for professional medical advice, diagnosis, or treatment.

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