Check My

Mixing Cocaine and Weed

We will give you the support and guidance you need to get started on the road of long-term recovery.

Get Help with Addiction Treatment

Mixing cocaine and marijuana (weed) can be dangerous and should be avoided. Cocaine and marijuana have different effects on the body and can lead to various physical and psychological symptoms. Cocaine is a stimulant that can increase heart rate, blood pressure, and body temperature, while marijuana is a depressant that can cause relaxation and sedation. When used together, these drugs can interact in ways that are difficult to predict and potentially detrimental.

Additionally, the use of illicit drugs, including cocaine and marijuana, is illegal and can have serious social, legal, and financial consequences. Therefore, it is vital to prioritize your health and well-being by avoiding illicit drugs and seeking help if you are struggling with substance use.

At Guardian Recovery, we encourage those struggling with drug dependence to reach out to us to learn more about our comprehensive treatment programs. Our licensed addiction specialists are equipped to provide individuals attempting to break free from polysubstance misuse with the skills, tools, and support they need to achieve their goals and reclaim the healthy, fulfilling lives they deserve.

Start Healing Today!

Choose recovery and take control of your life, it’s the path to a brighter future filled with health, happiness, and fulfillment.

How Are Weed & Cocaine Mixed & Used Together?

The combined use of weed (marijuana) and cocaine can be found among individuals seeking a more intense high than they previously achieved or in an attempt to counteract each drug’s undesirable effects. In many cases, the drugs are used simultaneously simply by ingesting them individually using their preferred method.

Another way to mix weed and cocaine is to smoke or inhale them together, such as by sprinkling cocaine on top of a bowl of marijuana, or rolling a joint or cigarette that contains both weed and cocaine, sometimes called a woolie. (1)

The Effects of Mixing a Stimulant & Depressant

Cocaine is a central nervous system stimulant, but marijuana’s effects are a bit more complex. Weed acts as both a stimulant and depressant and also a mild hallucinogen. (2) This is important because stimulants interact with each other in different ways than a stimulant does with a depressant.

Moreover, when used together, the effects of cocaine and weed can be challenging to predict and vary depending on the following factors:

  • The individual doses of cocaine and marijuana used.
  • The strain of marijuana, potency, and primary effects.
  • The purity/potency of cocaine.
  • Order in which drugs are taken (e.g., cocaine before marijuana or vice versa) or if taken simultaneously.
  • Method of administration for both drugs.
  • Individual factors, such as age and weight.
  • User expectations (good or bad).

Considering all the above factors, combining the two drugs can result in many possible effects, which can be more or less stimulating depending on the type of marijuana being used.

Potential Short & Long-Term Health Effects & Risks of Mixing Cocaine & Marijuana Include:

  • Euphoria or feelings of intense pleasure and reward.
  • Increased heart rate and blood pressure resulting from both substances, possibly leading to cardiovascular disease and heart attacks.
  • Impaired judgment, decision-making, memory, and cognitive impairments.
  • Mental health conditions such as anxiety, depression, panic attacks, paranoia, hallucinations, and psychosis.
  • Insomnia or sleep disturbances, reduced quality of sleep, and nightmares.
  • Tolerance, dependence, and addiction to one or both drugs.
  • Lung irritation, chronic bronchitis, and respiratory issues if smoked.
  • Damage to nasal passages if cocaine is snorted.
  • Infections and damage to veins if cocaine is injected.

Social, Legal, & Financial Effects of Cocaine & Marijuana Include:

  • Relationship conflicts due to ongoing drug use.
  • Social isolation and withdrawal in favor of drug use.
  • Arrests for drug possession or other charges.
  • Jail or prison time for drug-related convictions.
  • Financial struggles due to drug-related expenses.
  • Lost job opportunities related to ongoing drug use or criminal record.

Complimentary Insurance Check
Find Out Today!

"*" indicates required fields


How Does Weed Influence the Effects of Cocaine?

When used together, marijuana can produce sedation that may offset some of cocaine’s stimulating effects. This can be more or less true depending on whether the marijuana ingested has more stimulating or depressive effects. Conversely, the stimulating effects of cocaine may counteract marijuana-related sedation, potentially increasing alertness and energy levels.

The bottom line is that the effects of either drug can offset or exacerbate each other depending on many factors. Even if these factors are known, results can be unpredictable and also change significantly from the beginning to the end of use.

Overdose Risk

Cocaine overdose can occur even with a small amount of the drug and can result in a range of symptoms, including elevated heart rate, high blood pressure, fever, seizures, respiratory distress, and even death. The risk of overdose is higher when cocaine is taken in larger amounts or used in combination with other substances like alcohol, opioids, or benzodiazepines.

Marijuana, on the other hand, is not typically associated with fatal overdoses. (3) However, consuming too much marijuana can lead to uncomfortable symptoms like paranoia, anxiety, and a rapid heartbeat. In rare cases, consuming large amounts of marijuana can lead to more severe complications like psychosis or cardiovascular problems.

Risk of Dependence & Addiction

Cocaine and marijuana misuse tends to lead to dependence and addiction. Chronic cocaine and marijuana use each cause changes in the brain’s reward system, resulting in the development of a chemical or emotional reliance on these drugs and compulsive drug-seeking behavior. Polysubstance misuse can potentially increase the risk of addiction and its severity due to cross-tolerance, reinforcement, and increased impulsivity.

Cross-tolerance can occur when a person develops a tolerance to one substance and is predisposed to developing a tolerance to another substance with a similar effect. (4) For example, if a person develops a tolerance to cocaine, this can affect their response to other drugs with stimulating effects, including marijuana. This means they would need to use ever-increasing amounts of both these drugs to achieve the desired experience they’re seeking.

Reinforcement occurs when using one substance triggers cravings for the use of another. For example, if a person regularly uses cocaine and marijuana together, their brain will begin to perceive this association as rewarding. (5) Therefore, using one will trigger cravings for the other or vice versa. If this leads to increased drug use, dependence and addiction become more likely.

Finally, using multiple substances can increase impulsivity, thereby making an individual more likely to engage in risky behaviors, including further drug use. (6) Drugs that act on dopamine are among those closely associated with this tendency and can lead to a cycle of dangerous behavior that increases the likelihood of addiction.

Our Locations 

Our Facilities & Teams Transform Lives

Changing lives by providing comprehensive support and rehabilitation, empowering individuals to overcome addiction and regain control of their health and well-being.

Contact Guardian Recovery Today

Polysubstance misuse is more dangerous than the misuse of one drug or alcohol alone for many reasons. Using marijuana in an attempt to negate the adverse effects of cocaine or vice versa increases the likelihood of escalating drug use, addiction, and overdose. The combination of cocaine and weed can result in cardiovascular damage, heart attack, and stroke. Furthermore, weed affects cocaine’s availability in the bloodstream, increasing the risk of overdose.

Guardian Recovery is an innovative treatment center offering comprehensive programs and multiple levels of care, including medical detoxinpatient treatment, intensive outpatient caremedication-assisted treatment, and aftercare planning. Reach out to us to speak to a skilled Treatment Advisor to learn more about our streamlined admissions process and receive a free, no-obligation health benefits check.  Contact us today if you’re ready to begin your journey to long-lasting wellness and sobriety.


Do I have an Addiction issue?

Disclaimer: Does not guarantee specific treatment outcomes, as individual results may vary. Our services are not a substitute for professional medical advice or diagnosis; please consult a qualified healthcare provider for such matters.

Get Local Help

Helpful, Recovery

Reviewed professionally for accuracy by:

Ryan Soave


Ryan Soave brings deep experience as a Licensed Mental Health Counselor, certified trauma therapist, program developer, and research consultant for Huberman Lab at Stanford University Department of Neurobiology. Post-graduation from Wake Forest University, Ryan quickly discovered his acumen for the business world. After almost a decade of successful entrepreneurship and world traveling, he encountered a wave of personal and spiritual challenges; he felt a calling for something more. Ryan returned to school and completed his Master’s Degree in Mental Health Counseling. When he started working with those suffering from addiction and PTSD, he found his passion. He has never looked back.

Written by:

Cayla Clark

Cayla Clark

Cayla Clark grew up in Santa Barbara, CA and graduated from UCLA with a degree in playwriting. Since then she has been writing on addiction recovery and psychology full-time, and has found a home as part of the Guardian Recovery team.

More About Author

Check Insurance Coverage

Find out today what options are available to you. Fill out the form below.

Do it for YOU, Do it for LOVED ones

Live a BRIGHTER Future Today!

Guardian Recovery is here to assist you in your journey of healing.

Do it for YOU, Do it for LOVED ones

Contact Alumni Services Today!

Guardian Recovery is here to assist you in your journey of healing after coming to one of our facilities.

Your Name

Stay in touch ALUMNI

Join our alumni newsletter to get up to date information on events, news, and more.


Personalize Your Experience

Allow us to guide you to the information your looking for.

Begin HEALING Today
24/7 Help: (888) 693-1872