Can You Take Ibuprofen With Oxycodone?

We will give you the support and guidance you need to get started on the road of long-term recovery.

Get Help with Addiction Treatment

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). (1) It is used to help treat pain or inflammation caused by toothache, headache, back pain, minor injuries, menstrual cramps, and arthritis. (2) Ibuprofen can also be used to reduce fever. Ibuprofen can be used on individuals ages 6 months and older, and it can be found over the counter. (3)

Oxycodone is a semi-synthetic opioid that is used to treat chronic pain, pain caused by minor injuries, and pain following surgical procedures. Oxycodone is only legal for medical purposes as stated by the Drug Enforcement Administration. (4) Oxycodone is occasionally referred to as a narcotic. (5) Oxycodone is a substance that plays a major role in the opioid crisis. Oxycodone can lead to individuals experiencing temporary feelings of euphoria and relaxation, which are reasons that contribute to its addictive properties. (6)

If you or someone you know have difficulties controlling ibuprofen or oxycodone use, a substance use disorder may be present. Here at Guardian Recovery, we offer psychoeducation and evidence-based treatment for individuals experiencing alcohol and substance use disorders. With dual diagnosis treatment options for individuals experiencing substance use and mental health disorders simultaneously, you can focus on wellness and recovery in one location. Contact Guardian Recovery today to get started.

Start Healing Today!

Choose recovery and take control of your life, it’s the path to a brighter future filled with health, happiness, and fulfillment.

How Should Oxycodone & Ibuprofen Be Taken?

Since both oxycodone and ibuprofen help treat pain, many wonder can you take ibuprofen with oxycodone? Oxycodone and ibuprofen can be taken together if prescribed by a doctor. There is a combination medication of oxycodone and ibuprofen, known as Combunox. (7) Dosages are typically prescribed as 5mg of oxycodone and 400 mg ibuprofen. (8) The combination of oxycodone and ibuprofen is taken orally every 6 hours. (9) A maximum of 4 tablets can be taken within a 24 hour period. (10) The combination of oxycodone and ibuprofen should not be taken for more than a week. (11)

What You Should Discuss With Your Healthcare Provider Prior Taking

Before taking ibuprofen and oxycodone, you should discuss with your doctor if you should take other NSAIDs, such as aspirin. (12) You should also discuss if you take other prescription opioids.

Other important information that you should discuss with your doctor before taking ibuprofen and oxycodone together include: (13)

  • Whether or not you you drink alcohol
  • Whether or not you take blood thinners
  • Whether or not you take ACE inhibitors
  • Whether or not you take Lithium
  • Whether or not you take Furosemide
  • If you have ever had high blood pressure
  • If you have ever had stomach bleeding or ulcers
  • If you have breathing problems
  • If you have ever experienced any head trauma
  • If you have ever experienced seizures

Are There Medications That Should Not Be Taken With Opioids?

Due to how oxycodone interacts with the brain and body, there are certain medications that can not be taken with it simultaneously.

Combining opioids with other substances that slow down the central nervous system can increase one’s chances of experiencing an overdose. (14)

Central nervous system depressants include: (15)

  • Benzodiazepines
  • Alcohol
  • Barbiturates
  • Xylazine
  • Clonazepam (Klonopin)
  • Zaleplon (Sonata)
  • Zolpidem (Ambien)
  • Eszopiclone (Lunesta)

Mixing oxycodone with other opioids can also increase one’s chances of experiencing an overdose.

Other prescription opioids include: (16)

  • Hydrocodone (Vicodin)
  • Oxymorphone (Opana)
  • Morphine (Kadian, Avinza)
  • Codeine
  • Fentanyl
  • Tapentadol
  • Hydromorphone
  • Methadone

Drug Interactions & Risks

Drug interactions occur when another substance interferes with the effectiveness of a medication. There are 800 medications that may interact with combined ibuprofen and oxycodone. (17) Interactions may be minor, moderate, or major.

Some medications that may cause drug interactions when used in combination with ibuprofen and oxycodone include: (18)

  • Other opioids
  • Cold or allergy medications
  • Medications used for COPD
  • Medications used for motion sickness
  • Medications used for irritable bowel syndrome
  • Medications used for bladder issues
  • Sedative medications such as Valium, Xanax, or Klonopin
  • Muscle relaxers or sleeping medications
  • Medications used to help treat mental health disorders
  • Medications used to help treat Parkinson’s disease

Complimentary Insurance Check
Find Out Today!

"*" indicates required fields

Name
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Important Warnings & Facts to Know When Taking the Two Together

Ibuprofen can increase the chances of an individual experiencing a fatal heart attack or stroke. (19) Ibuprofen can also cause stomach or intestinal bleeding. (20) Engaging in hazardous activities or operating a motor vehicle should be avoided when taking ibuprofen and oxycodone together. (21) An individual should not take ibuprofen and oxycodone before or after receiving heart bypass surgery. (22)

Potential Symptoms & Side Effects of Oxycodone & Ibuprofen

All substances produce some sort of side effect, whether they are mild, moderate, or severe.

Common side effects associated with combined oxycodone and ibuprofen use include: (23)

  • Drowsiness or dizziness
  • Blurry vision
  • Stomach pain
  • Nausea or vomiting
  • Constipation
  • Diarrhea

More serious side effects can occur with oxycodone and ibuprofen use. Contact your doctor if you experience more serious side effects.

Serious side effects associated with oxycodone and ibuprofen include: (24)

  • Heavy breathing
  • Slowing breathing
  • Breathing that may stop during sleep
  • Weight gain that occurs quickly
  • Skin rash
  • Pale skin
  • Lightheadedness
  • Bloody or tarry stools
  • Coughing up blood
  • Kidney impairments
  • Liver impairments
  • Mood swings
  • Fever
  • Hallucinations

Addiction & Overdose Potential of Ibuprofen & Oxycodone

Since the combination of ibuprofen and oxycodone contains an opioid, the lowest dose for the shortest amount of time is often given in order to reduce the risk of addiction. Taking an opioid can lead to addiction even if it is prescribed by a doctor. In 2021, approximately 14.3 million individuals, ages 12 years and older, reported engaging in the misuse of prescription medications within a 12 month period. (25) Approximately 5 million individuals were diagnosed with an opioid use disorder during the same year. (26)

Approximately 16,706 individuals experienced a fatal overdose due to prescription opioid use in 2021. (27) Understanding the signs of an overdose caused by taking ibuprofen and oxycodone together is important in order to ensure that the appropriate steps are taken.

Signs of an overdose caused by the combination of oxycodone and ibuprofen include: (28)

  • Chest pain
  • Cold or clammy skin
  • Small pupils
  • Hearing unexplained noises such as ringing or buzzing
  • Decreased awareness
  • Decreased responsiveness
  • Trouble breathing
  • Difficulties falling or staying asleep
  • Drowsiness
  • Disorientation
  • Changes in consciousness
  • Lethargy
  • Inability to control bladder
  • Muscles spasms
  • Pale or blue skin
  • Being unable to hear
  • Fainting
  • Coma

If you or someone you know experiences any of the above symptoms after taking ibuprofen and oxycodone together, seek immediate emergency care as overdoses can be fatal.

Our Locations 

Our Facilities & Teams Transform Lives

Changing lives by providing comprehensive support and rehabilitation, empowering individuals to overcome addiction and regain control of their health and well-being.

Contact Us Today to Learn More

Here at Guardian Recovery, we understand the toll that substance use takes on an individual and their loved one. We provide individualgroup, and family therapy to help individuals identify the root of their dependence. Contact us to speak with one of our Treatment Advisors who will help you begin your recovery journey. A free, no obligation insurance benefit check can be provided upon your request. Start your addiction recovery journey with Guardian Recovery.

SELF-ASSESSMENT:

Do I have an Addiction issue?

Disclaimer: Does not guarantee specific treatment outcomes, as individual results may vary. Our services are not a substitute for professional medical advice or diagnosis; please consult a qualified healthcare provider for such matters.

  1. https://www.drugs.com/ibuprofen.html
  2. https://www.drugs.com/ibuprofen.html
  3. https://www.drugs.com/ibuprofen.html
  4. https://www.dea.gov/drug-information/drug-scheduling
  5. https://www.drugs.com/oxycodone.html#interactions
  6. https://www.dea.gov/sites/default/files/2020-06/Oxycodone-2020_0.pdf
  7. https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021378s006lbl.pdf
  8. https://www.drugs.com/mtm/ibuprofen-and-oxycodone.html
  9. https://www.drugs.com/mtm/ibuprofen-and-oxycodone.html
  10. https://www.drugs.com/mtm/ibuprofen-and-oxycodone.html
  11. https://www.drugs.com/mtm/ibuprofen-and-oxycodone.html
  12. https://www.drugs.com/mtm/ibuprofen-and-oxycodone.html#before-taking
  13. https://www.arthritis.org/drug-guide/analgesics/oxycodone-with-ibuprofen
  14. https://nida.nih.gov/research-topics/opioids/benzodiazepines-opioids#:~:text=Co%2DPrescribing%20Opioids%20and%20Benzodiazepines&text=Combining%20opioids%20and%20benzodiazepines%20can,addition%20to%20impairing%20cognitive%20functions.
  15. https://nida.nih.gov/research-topics/opioids/benzodiazepines-opioids#:~:text=Co%2DPrescribing%20Opioids%20and%20Benzodiazepines&text=Combining%20opioids%20and%20benzodiazepines%20can,addition%20to%20impairing%20cognitive%20functions.
  16. https://www.cdc.gov/rxawareness/information/index.html
  17. https://www.drugs.com/drug-interactions/ibuprofen-oxycodone.html
  18. https://www.cdc.gov/rxawareness/information/index.html
  19. https://www.drugs.com/mtm/ibuprofen-and-oxycodone.html
  20. https://www.drugs.com/mtm/ibuprofen-and-oxycodone.html
  21. https://www.drugs.com/mtm/ibuprofen-and-oxycodone.html
  22. https://www.drugs.com/mtm/ibuprofen-and-oxycodone.html
  23. https://www.drugs.com/sfx/ibuprofen-oxycodone-side-effects.html
  24. https://www.drugs.com/sfx/ibuprofen-oxycodone-side-effects.html
  25. https://nida.nih.gov/publications/research-reports/misuse-prescription-drugs/what-scope-prescription-drug-misuse
  26. https://nida.nih.gov/publications/research-reports/misuse-prescription-drugs/what-scope-prescription-drug-misuse
  27. https://nida.nih.gov/publications/research-reports/misuse-prescription-drugs/what-scope-prescription-drug-misuse
  28. https://www.drugs.com/sfx/ibuprofen-oxycodone-side-effects.html

Get Local Help

Helpful, Recovery
Resources

Reviewed professionally for accuracy by:

Ryan Soave

L.M.H.C.

Ryan Soave brings deep experience as a Licensed Mental Health Counselor, certified trauma therapist, program developer, and research consultant for Huberman Lab at Stanford University Department of Neurobiology. Post-graduation from Wake Forest University, Ryan quickly discovered his acumen for the business world. After almost a decade of successful entrepreneurship and world traveling, he encountered a wave of personal and spiritual challenges; he felt a calling for something more. Ryan returned to school and completed his Master’s Degree in Mental Health Counseling. When he started working with those suffering from addiction and PTSD, he found his passion. He has never looked back.

Written by:

Picture of Cayla Clark

Cayla Clark

Cayla Clark grew up in Santa Barbara, CA and graduated from UCLA with a degree in playwriting. Since then she has been writing on addiction recovery and psychology full-time, and has found a home as part of the Guardian Recovery team.

More About Author
Guardian Recovery

Check Insurance Coverage

Find out today what options are available to you. Fill out the form below.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Do it for YOU, Do it for LOVED ones

Live a BRIGHTER Future Today!

Guardian Recovery is here to assist you in your journey of healing.

Do it for YOU, Do it for LOVED ones
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Live a BRIGHTER Future Today!

Guardian Recovery is here to assist you in your journey of healing.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Do it for YOU, Do it for LOVED ones

Contact Alumni Services Today!

Guardian Recovery is here to assist you in your journey of healing after coming to one of our facilities.

Your Name
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Stay in touch ALUMNI

Join our alumni newsletter to get up to date information on events, news, and more.

Name
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Personalize Your Experience

Allow us to guide you to the information your looking for.

Begin HEALING Today

Check Insurance Coverage

Find out today what options are available to you. Fill out the form below.

Do it for YOU, Do it for LOVED ones

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
24/7 Help: (888) 693-1872