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Oxycodone vs Dilaudid as Pain Relievers

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The nation is in the midst of an opioid epidemic, which can be largely attributed to the overprescription of narcotic painkillers. Many individuals begin developing an opioid use disorder after being given a legitimate prescription due to an injury or surgical procedure, but because of their addictive nature, patients progress to using these drugs in excess or opting for more potent and often illegal opioids like heroin.  As America continues to remain a global leader (1) in the prescription of opioids, two of the substances that often enter the discussion are oxycodone and Dilaudid.

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What Is Oxycodone?

Among one of the most popular prescription opioids for the last decade, oxycodone (2) is a powerful semi-synthetic opioid. Semi-snthetic means that it contains both chemically manufactured as well as natural elements. The naturally occurring element of oxycodone is synthesized from thebaine, a constituent of the poppy plant. It is often referred to by its brand name OxyContin.

What Is Dilaudid?

Dilaudid (3) is the brand name for another powerful opiate called hydromorphone. Hydromorphone is also considered a semisynthetic opiate due to its makeup consisting of derivatives of morphine, the liquid extracted from the seed pod of the poppy plant.

Oxycodone & Dilaudid Drug Classification & Regulation

Both oxycodone and Dilaudid are classified as opioids due to their reaction with the brain and body as well as the presence of extracts of the naturally occurring poppy plant. Due to their medical usage along with their highly addictive nature, they are classified by the Drug Enforcement Administration (DEA) as a Schedule II controlled substance. This Schedule makes both of these substances among the highest for the possibility of addiction.

Similarities Between Oxycodone & Dilaudid

Both of these powerful controlled substances are classified as semi-synthetic opioids. This means that they contain both naturally occurring chemical compounds as well as manufactured ones.

Purpose & Uses

Each of these substances have powerful pain relieving properties and are prescribed by medical professionals for this purpose. They are both often prescribed for patients recovering from surgery or patients who are undergoing cancer treatments. Dilaudid is known to be significantly more potent than oxycodone as well as remaining in the user’s system longer to provide a greater period of pain relief before the next dosage is required.

Chemical Effects on the Brain

Oxycodone and Dilaudid are both opioids meaning that they interact with the brain and body’s opioid receptors stopping the pain signals from being communicated throughout the body. This is what gives them such powerful pain relieving properties. They also interact with the brain’s reward system causing large amounts of chemicals like dopamine to be introduced into the brain. This leads the user to feel euphoric and potentially begin cycles of addiction.

Generic Names for Commercial Brands

Oxycodone is the generic name but may be better known by its brand name OxyContin. Dilaudid is the brand name for the compound hydromorphone.

Extended Release

Though Dilaudid has a longer window of effectiveness, both oxycodone and Dilaudid are manufactured in time-released forms to prevent them from being used recreationally.

Differences Between Dilaudid & Oxycodone

One of the major differences between oxycodone and Dilaudid (hydromorphone) is their strength.  In fact, 1 mg of hydromorphone is equivalent to 2.67 mg of oxycodone. This means that hydromorphone is nearly 2.5 times stronger than oxycodone. Another factor that plays a key role in which prescription is chosen is the amount of time that each substance will provide pain relief. Dilaudid has a longer window of effectiveness than oxycodone therefore requiring dosage less often for the same effect.

What Are the Different Forms They Can Be Taken?

Both of these potent substances are only available in time released tablets for oral ingestion. Due to the high number of people using these substances illicitly, time release capsules that do not have the ability to be crushed are the only available forms.

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Which Acts More Quickly & Is Stronger for Pain Management?

Though both have a time released onset oxycodone will begin to deliver its pain relieving properties between 10 and 30 minutes, while dilaudid will take up to 8 hours (4) for the full effect to be felt but is able to remain in the system providing pain relief for up to 24 hours. Dilaudid is significantly stronger than oxycodone, however. 1 mg of hydromorphone is equivalent to 2.67 mg of oxycodone. This means that hydromorphone is nearly 2.5 times stronger than oxycodone.

Common Side Effects

Common side effects (5) of both oxycodone and Dilaudid include:

  • Constipation
  • Feeling or being sick (nausea or vomiting)
  • Stomach discomfort
  • Feeling sleepy or tired
  • Feeling dizzy and a sensation of spinning (vertigo)
  • Confusion
  • Headaches
  • Itchiness or rash

Withdrawal Symptoms

After extended periods of regular use, your body can develop a dependence on opioids. After suddenly stopping their use, many will begin to feel withdrawal symptoms (6) that may include:

  • Agitation
  • Muscle aches
  • Restlessness
  • Anxiety
  • Runny nose
  • Excessive sweating
  • Inability to sleep
  • Yawning often
  • Diarrhea
  • Nausea and vomiting
  • Skin goose bumps
  • Rapid heartbeat

What Are the Pros & Cons Between the Two?

The pros for both oxycodone and Dilaudid are that they are powerful pain relieving substances that, when used correctly, provide much needed relief to those who suffer from chronic pain or are recovering from a surgical procedure. Cons can include their various side effects as well as the potential for addiction. Oxycodone will provide a quicker onset of pain relief, however, Dilaudid will provide a longer pain relief and will not require dosage as often.

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Which Is More Likely to Cause Abuse or Dependence?

Both substances are classified by the DEA as Schedule II controlled substances. This means that both are extremely high in the possibility that they will cause addictive patterns of use.

If you or someone that you know is struggling with an opioid use disorder, there is hope. Guardian Recovery is available 24/7 to provide the best possible quality of substance use treatment available. Our trained staff is standing by now to take your call. They will be able to answer any questions that you have about the treatment process and can even conduct a free no obligation insurance check. Call today to begin your journey to freedom.

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  1. https://crsreports.congress.gov/product/pdf/R/R46805
  2. https://pubchem.ncbi.nlm.nih.gov/compound/oxycodone
  3. https://www.medicine.com/drug/hydromorphone/hcp
  4. https://reference.medscape.com/drug/dilaudid-hydromorphone-343313
  5. https://www.nhs.uk/medicines/oxycodone/side-effects-of-oxycodone/
  6. https://www.ncbi.nlm.nih.gov/books/NBK526012/

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Reviewed professionally for accuracy by:

Ryan Soave

L.M.H.C.

Ryan Soave brings deep experience as a Licensed Mental Health Counselor, certified trauma therapist, program developer, and research consultant for Huberman Lab at Stanford University Department of Neurobiology. Post-graduation from Wake Forest University, Ryan quickly discovered his acumen for the business world. After almost a decade of successful entrepreneurship and world traveling, he encountered a wave of personal and spiritual challenges; he felt a calling for something more. Ryan returned to school and completed his Master’s Degree in Mental Health Counseling. When he started working with those suffering from addiction and PTSD, he found his passion. He has never looked back.

Written by:

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Cayla Clark

Cayla Clark grew up in Santa Barbara, CA and graduated from UCLA with a degree in playwriting. Since then she has been writing on addiction recovery and psychology full-time, and has found a home as part of the Guardian Recovery team.

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The information provided on this website is intended solely for educational and informational purposes. Guardian Recovery aims to improve the quality of life for individuals struggling with substance use or mental health disorders by offering fact-based content about behavioral health conditions, treatment options, and related outcomes. However, this information should not be considered a substitute for professional medical advice, diagnosis, or treatment.

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